ProNeurogen Peptides are Selective Mas Receptor Agonists

•Ang-(1-7) is a member of the Renin-Angiotensin family

•Binds to small GPCR Mas receptor

•Ang-(1–7) activation of Mas results in inhibition of inflammation, ROS and increased brain blood flow via activation of e-NOS.

•Through these mechanisms, Ang-(1–7) actions result in neuroprotection and improved memory function.